Integrative analysis of the role of BOLA2B in human pan-cancer
Abstract Objective:BOLA2B is a recently discovered protein-coding gene. Here, pan-cancer analysis was conducted to determine the expression patterns of BOLA2B…
Anti-proliferation
Tetrahydrocurcumin regulates the tumor immune microenvironment to inhibit breast cancer proliferation and metastasis via the CYP1A1/NF-κB signaling pathway
Abstract The NF-κB signaling pathway is overactivated in tumor cells, and the activation of the NF-κB signaling pathway releases a…
Suppression of Calcium Entry Modulates the Expression of TRβ1 and Runx2 in Thyroid Cancer Cells, Two Transcription Factors That Regulate Invasion, Proliferation and Thyroid-Specific Protein Levels
Abstract Simple Summary: Thyroid cancer is the most common endocrine cancer and the treatment for such hostile tumors remains a…
An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers
Abstract Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved…
Cannabinol Inhibits Cellular Proliferation, Invasion, and Angiogenesis of Neuroblastoma via Novel miR-34a/tRiMetF31/PFKFB3 Axis
Abstract Simple Summary: The prognosis of high-risk neuroblastoma is poor due to its high relapse rate. To date, no effective…
N6-Methyladenosine Methylation Regulator RBM15 is a Potential Prognostic Biomarker and Promotes Cell Proliferation in Pancreatic Adenocarcinoma
Abstract RNA binding motif protein 15 (RBM15) is a key regulatory factor involved in N6-methyladenosine (m6A) methylation. It has been…
MicroRNA-200c-3p Negatively Regulates ATP2A2 and Promotes the Progression of Papillary Thyroid Carcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10528-022-10184-w. Article type: Research Article Keywords: microRNA, Papillary thyroid…
Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00018-021-03880-0. Article type: Research Article Keywords: Thyroid cancer, Stromal…
Cannabinoid Receptor Modulation of Neurogenesis: ST14A Striatal Neural Progenitor Cells as a Simplified In Vitro Model
Abstract The endocannabinoid system (ECS) is involved in the modulation of several basic biological processes, having widespread roles in neurodevelopment,…
Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s13105-021-00789-x. Article type: Research Article Keywords: Adiponectin, Leptin, Thyroid…