MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma
Abstract MZT2A is a novel core component in the γ-tubulin ring complex and aberrantly expressed in some types of tumors.…
Anti-proliferation
Exercise-downregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer
Abstract Background: Breast cancer ranks as one of the most prevalent malignancies among women globally, with increasing incidence rates. Physical…
Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma
Abstract Recent studies indicate that Glypican 1 (GPC-1) is aberrantly expressed and plays a key role in certain cancers, but…
Integrated pan-cancer genomic analysis reveals the role of SLC30A5 in the proliferation, metastasis, and prognosis of hepatocellular carcinoma
Abstract Background: SLC30A5, a member of the solute transporter protein family, is implicated in tumorigenesis and cancer progression. This study…
Revolutionary multi-omics analysis revealing prognostic signature of thyroid cancer and subsequent in vitro validation of SNAI1 in mediating thyroid cancer progression through EMT
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10238-024-01387-z. Article type: Research Article Keywords: Multi-omics analysis, Thyroid…
Experimental Validation and Multi-omics Analysis Identified ARPC1A as a Novel Oncogene and Potential Therapeutic Target in Glioblastoma
Abstract Actin-related protein 2/3 complex subunit 1A (ARPC1A) is implicated in several cancers due to its critical role in regulating…
Comprehensive analysis to identify PUS7 as a prognostic biomarker from pan-cancer analysis to osteosarcoma validation
Abstract Aim: Pseudouridylation has demonstrated the potential to control the development of numerous malignancies. PUS7(Pseudouridine Synthase 7) is one of…
IRX5’s influence on macrophage polarization and outcome in papillary thyroid cancer
Abstract Background: With a rise in recent years, thyroid cancer (TC) is the most prevalent hormonal cancer worldwide. It is…
Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model
Abstract Human pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and lethal tumor of the exocrine pancreas. Cannabinoids extracted from…
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target
Abstract Purpose: Pancreatic cancer (PC) is a highly malignant tumor that poses a severe threat to human health. Brain glycogen…