Cannabinoids as Glial Cell Modulators in Ischemic Stroke: Implications for Neuroprotection
Abstract Stroke is the second leading cause of death worldwide following coronary heart disease. Despite significant efforts to find effective…
anti-neuroinflammation
Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities
Abstract Autism spectrum disorder (ASD) and associated neurodevelopmental disorders share similar pathogenesis and clinical features. Pathophysiological changes in these diseases…
Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans
Abstract Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the…
Parkinson’s Disease and SARS-CoV-2 Infection: Particularities of Molecular and Cellular Mechanisms Regarding Pathogenesis and Treatment
Abstract Accumulating data suggest that chronic neuroinflammation-mediated neurodegeneration is a significant contributing factor for progressive neuronal and glial cell death…
Anti-Inflammatory Effect of Beta-Caryophyllene Mediated by the Involvement of TRPV1, BDNF and trkB in the Rat Cerebral Cortex after Hypoperfusion/Reperfusion
Abstract We have previously shown that bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R) is a model to study…
Neurological Benefits, Clinical Challenges, and Neuropathologic Promise of Medical Marijuana: A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination
Abstract Despite current therapeutic strategies for immunomodulation and relief of symptoms in multiple sclerosis (MS), remyelination falls short due to…
The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation
Abstract Microglia, the resident immune cells of the brain, can take on a range of pro- or anti-inflammatory phenotypes to…
Hempseed (Cannabis sativa) Peptides WVSPLAGRT and IGFLIIWV Exert Anti-inflammatory Activity in the LPS-Stimulated Human Hepatic Cell Line
Abstract WVSPLAGRT (H2) and IGFLIIWV (H3) are two transepithelial transported intestinal peptides obtained from the hydrolysis of hempseed protein with…
The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models
Abstract Epilepsy is one of the most common neurological conditions. Yearly, five million people are diagnosed with epileptic-related disorders. The…
Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Abstract Major depressive disorder is a high-impact, debilitating disease and it is currently considered the most prevalent mental illness. It…