The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) is characterized by massive neuronal death, brain atrophy, and loss of neurons and synapses, which all…
anti-neuroinflammation
Nicotine, THC, and Dolutegravir Modulate E-Cigarette-Induced Changes in Addiction- and Inflammation-Associated Genes in Rat Brains and Astrocytes
Abstract E-cigarette use has been marketed as a safer alternative to traditional cigarettes, as a means of smoking cessation, and…
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Abstract Alzheimer’s disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of…
Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System
Abstract Neuroinflammation is a complex biological process that typically originates as a protective response in the brain. This inflammatory process…
The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in AppNL-G-F Knock-In Mice
Abstract Simple Summary: Alzheimer’s disease (AD) is a complex, multifactorial disease where numerous components, such as environment, lifestyle, comorbidities, and…
Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders
Abstract During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of…
Endocannabinoid system components as potential neuroimmune therapeutic targets in tinnitus
Abstract Research interest in understanding tinnitus has increased severalfold in the last decade to find a cure for this auditory…
Cannabidiol in the acute phase of febrile infection‐related epilepsy syndrome (FIRES)
Abstract Febrile infection‐related epilepsy syndrome (FIRES) is a prolonged refractory status epilepticus (SE) that develops among healthy individuals after a…
Deletion of Cryab increases the vulnerability of mice to the addiction-like effects of the cannabinoid JWH-018 via upregulation of striatal NF-κB expression
Abstract Synthetic cannabinoids have exhibited unpredictable abuse liabilities, especially self-administration (SA) responses in normal rodent models, despite seemingly inducing addiction-like…
Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity
Abstract Introduction: The implications of maternal overnutrition on offspring metabolic and neuroimmune development are well-known. Increasing evidence now suggests that…