The effects of far-red light on medicinal Cannabis
Abstract Far-red (FR) light elicits two distinct processes in plants. First, a shade avoidance response which is triggered when the…
Animal physiology
Alterations of the endocannabinoid system in adolescents with non-suicidal self-injury as a function of childhood maltreatment
Abstract Non-suicidal self-injury (NSSI) is a highly prevalent phenomenon in adolescence, often associated with prior traumatic experiences. The development and…
Data-driven dynamic profiles of tonic heat pain perception in pain-free volunteers are associated with differences in anandamide levels
Abstract Our laboratory previously developed a method for assessing experimentally induced pain perception through a 2-min constant heat pain stimulation.…
Cannabidiol effectively prevents oxidative stress and stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) in an animal model of global hypoxia
Abstract Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis sativa. It has therapeutic effects in different paradigms of brain…
Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons
Abstract The authors use high-content calcium imaging and patch clamp recordings to demonstrate broad inhibition by cannabidiol of multiple receptors,…
Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids
Abstract Plasticity during the critical period is important for the functional maturation of cortical neurons. While characteristics of plasticity are…
Impairment of Endothelial Function by Aerosol From Marijuana Leaf Vaporizers
Abstract Background: Marijuana leaf vaporizers, which heat plant material and sublimate Δ‐9‐tetrahydrocannabinol without combustion, are popular alternatives to smoking cannabis…
Fetal cannabidiol (CBD) exposure alters thermal pain sensitivity, problem-solving, and prefrontal cortex excitability
Abstract Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated with cannabidiol (CBD), a primary…
Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows
Abstract Metabolic disorders are often linked to alterations in insulin signaling. Omega-3 (n-3) fatty acids modulate immunometabolic responses; thus, we…
In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner
Abstract Cannabidiol (CBD), one of the main components of cannabis, is generally considered safe. CBD crosses the placenta and its…