Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence
Abstract Depression is characterized by continuous low mood and loss of interest or pleasure in enjoyable activities. First-line medications for…
animal models of depression
An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample
Abstract Background: Little is known about cannabis use for insomnia in individuals with depression, anxiety, and comorbid depression and anxiety.…
Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice
Abstract The anxiolytic and antidepressant properties of cannabidiol (CBD) have been evaluated in several studies. However, the molecular mechanisms involved…
In Vitro Effects of Cannabidiol on Activated Immune–Inflammatory Pathways in Major Depressive Patients and Healthy Controls
Abstract Major depressive disorder and major depressive episodes (MDD/MDE) are characterized by the activation of the immune–inflammatory response system (IRS)…
Cannabidiol (CBD) in the Self-Treatment of Depression-Exploratory Study and a New Phenomenon of Concern for Psychiatrists
Abstract Cannabis sativa, whose flowers are also known as marijuana or marihuana, is a recreational plant that contains many chemicals…
Gender Differences in Dual Diagnoses Associated with Cannabis Use: A Review
Abstract Gender differences in psychiatric disorders and drug use are well known. Cannabis is the most widely used illegal drug…
Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial
Abstract Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders,…
Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update
Abstract Chronic neuropathic pain (CNP) is a disabling medical condition that impairs the health-related quality-of-life of affected patients. A high…
The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases
Abstract The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a balance in internal environment (temperature, mood, and immune…
The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health
Abstract According to the World Health Organization (WHO), 47 million people display mental health disorders Worldwide. In addition, epidemiological studies…