Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic
Abstract Background: Cannabidiol (CBD) is a primary component in the cannabis plant; however, in recent years, interest in CBD treatments…
animal models of depression
Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine Pathway in Depression
Abstract Substance use/abuse is one of the main causes of depressive symptoms. Cannabis and synthetic cannabinoids in particular gained significant…
Down and High: Reflections Regarding Depression and Cannabis
Abstract In light of the recent changes in the legal status of cannabis in Canada, the understanding of the potential…
Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico–Striatal Loop That Are Implicated in Major Depression
Abstract Depression, the most prevalent psychiatric disorder in the Western world, is characterized by increased negative affect (i.e., depressed mood,…
Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review
Abstract Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several…
Effects of Chronic Exposure to Low-Dose delta-9-Tetrahydrocannabinol in Adolescence and Adulthood on Serotonin/Norepinephrine Neurotransmission and Emotional Behavior
Abstract Background: Chronic exposure to D9-tetrahydrocannabinol (THC), the main pharmacological component of cannabis, during adolescence has been shown to be…
The Effectiveness of Cannabis Flower for Immediate Relief from Symptoms of Depression
Abstract Objective: Scientific research on how consumption of whole, natural Cannabis flower affects low mood and behavioral motivations more generally…
Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression
Abstract Several neuropharmacological actions of cannabidiol (CBD) due to the modulation of the endocannabinoid system as well as direct serotonergic…
Depression Onset in Long-term Adolescent Cannabinoid Use: A Neurobiological Review
Abstract Escalating cannabis use may be linked to decreased motivation and anhedonia, which are symptoms of depression. Adolescent cannabis users…
Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand
Abstract Background: Cannabidiol (CBD) is the non-euphoriant component of cannabis. In 2017, the New Zealand Misuse of Drugs Regulations (1977)…