GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration
Abstract Human immunodeficiency virus type 1 (HIV-1) is known to provoke microglial immune responses which likely play a paramount role…
anandamide
Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation
Abstract Simple Summary: Pro-inflammatory cytokines are considered to be one of the most important mediators affecting the function of central…
The endocannabinoid system in the amygdala and modulation of fear
Abstract Posttraumatic stress disorder (PTSD) is a persistent, trauma induced psychiatric condition characterized by lifelong complex cognitive, emotional and behavioral…
The Influence of Anandamide on the Anterior Pituitary Hormone Secretion in Ewes—Ex Vivo Study
Abstract Simple Summary: Mankind has been using Cannabis sativa (marijuana) for a century, but the system of endogenous cannabinoids has…
Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism
Abstract We investigated the influence of cannabidiol (CBD) on blood pressure (BP) and heart rate (HR) in spontaneously (SHR) and…
The Endocannabinoid System of Animals
Abstract Simple Summary: Our understanding of the Endocannabinoid System of animals, and its ubiquitous presence in nearly all members of…
Acute Administration of URB597 Fatty Acid Amide Hydrolase Inhibitor Prevents Attentional Impairments by Distractors in Adolescent Mice
Abstract The maturation of attentional control during adolescence might influence later functional outcome or predisposition to psychiatric disorders. During adolescence,…
Lower circulating endocannabinoid levels in children with autism spectrum disorder
Abstract Background: The endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have…
Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation
Abstract Endocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple…
Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
Abstract The plant Cannabis sativa contains cannabinoids represented by Δ9-tetrahydrocannabinol, which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2…