Lower circulating endocannabinoid levels in children with autism spectrum disorder
Abstract Background: The endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have…
anandamide
Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation
Abstract Endocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple…
Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
Abstract The plant Cannabis sativa contains cannabinoids represented by Δ9-tetrahydrocannabinol, which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2…
Endocannabinoid-Enhanced “Liking” in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals
Abstract Introduction: Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial “hedonic hotspot” in nucleus accumbens (NAc) shell enhances…
Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy
Abstract Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well-known side…
Cannabinoid ligands, receptors and enzymes: Pharmacological tools and therapeutic potential
Abstract Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of…
Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention
Abstract Introduction: The endocannabinoid system (ECS) regulates functions throughout human physiology, including neuropsychiatric, cardiovascular, autonomic, metabolic, and inflammatory states. The…
Cannabis and Pain: A Clinical Review
Abstract Introduction: Cannabis has been used for medical purposes across the world for centuries. As states and countries implement medical…
A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)
Abstract This perspective was adapted from a Career Achievement Award talk given at the International Cannabinoid Research Society Symposium in…
Endocannabinoid system: Role in depression, reward and pain control (Review)
Abstract Depression and pain co-exist in almost 80% of patients and are associated with impaired health-related quality of life, often…