Pro-Apoptotic Effects of Anandamide in Human Gastric Cancer Cells Are Mediated by AKT and ERK Signaling Pathways
Abstract Gastric cancer is one of the most common forms of cancer worldwide. A growing number of studies have addressed…
anandamide
Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells
Abstract Endocannabinoids have been shown to play a complex role in the pathophysiology of a number of cardiovascular disorders. In…
Data-driven dynamic profiles of tonic heat pain perception in pain-free volunteers are associated with differences in anandamide levels
Abstract Our laboratory previously developed a method for assessing experimentally induced pain perception through a 2-min constant heat pain stimulation.…
Effect of central administration of indomethacin on anandamide-induced GnRH/LH secretion in the hypothalamus of anoestrous ewes
Abstract Introduction: It is suggested that cannabinoids (CBs) may disturb reproduction through action on hypothalamic gonadotropin-releasing hormone (GnRH) neurons directly…
Endocannabinoid levels in plasma and neurotransmitters in the brain: a preliminary report on patients with a psychotic disorder and healthy individuals
Abstract Background: Interactions between the endocannabinoid system (ECS) and neurotransmitter systems might mediate the risk of developing a schizophrenia spectrum…
Exploring the versatile roles of the endocannabinoid system and phytocannabinoids in modulating bacterial infections
Abstract The endocannabinoid system (ECS), initially identified for its role in maintaining homeostasis, particularly in regulating brain function, has evolved…
Extracellular vesicles released by microglia and macrophages carry endocannabinoids which foster oligodendrocyte differentiation
Abstract Introduction: Microglia and macrophages can influence the evolution of myelin lesions through the production of extracellular vesicles (EVs). While…
Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study
Abstract Background: The effects of cannabis are thought to be mediated by interactions between its constituents and the endocannabinoid system.…
Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults
Abstract Context: The endocannabinoid system (ECS) is a signaling system composed of endocannabinoids (eCBs), their receptors, and the enzymes involved…
Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies
Abstract Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body.…