Abstract Introduction: Pain, particularly cramping, in people living with amyotrophic lateral sclerosis (ALS) is often underrecognized and under-treated. Despite affecting…
Abstract Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting voluntary muscle movement as well as cognitive and…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10072-024-07643-0. Article type: Review Article Keywords: Amyotrophic lateral sclerosis,…
Abstract Oxygen is a central molecule for numerous metabolic and cytophysiological processes, and, indeed, its imbalance can lead to numerous…
Abstract Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the…
Abstract Medical use of cannabis has been receiving growing attention over the last few decades in modern medicine. As we…
Abstract In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5),…
Abstract Background: Neuropathic symptoms have a wide variety of manifestations, ranging from pain to pruritus. Neuropathic pruritus is a type…
Abstract Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou Gehrig’s disease, is characterized by a…
Abstract One of the defining pathological features of Alzheimer’s disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of…