Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides
Abstract Despite the pivotal importance of the ubiquitin–proteasome pathway to the survival of Plasmodium, the parasite causing malaria, there is…
Amyloid beta-peptides
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-024-01758-3. Article type: Research Article Keywords: Cerebrospinal fluid, Biomarkers,…
Simplified cloning and isolation of peptides from “sandwiched” SUMO-peptide-intein fusion proteins
Abstract Background: Some peptides are targets for degradation when heterologously expressed as fusion proteins in E. coli, which can limit…
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation
Abstract Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights…
Computer-Aided Screening for Potential Coronavirus 3-Chymotrypsin-like Protease (3CLpro) Inhibitory Peptides from Putative Hemp Seed Trypsinized Peptidome
Abstract To control the COVID-19 pandemic, antivirals that specifically target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently…
Targeting PirAvp and PirBvp Toxins of Vibrio parahaemolyticus with Oilseed Peptides: An In Silico Approach
Abstract Acute hepatopancreatic necrosis disease (AHPND), caused by PirAvp– and PirBvp-releasing Vibrio parahaemolyticus strains, has resulted in massive mortality in…
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Abstract Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved…