Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer
Abstract Liver hepatocellular carcinoma (LIHC) is the major form of liver cancer that is the fourth most common cause of…
algorithm analysis
DEPTH2: an mRNA-based algorithm to evaluate intratumor heterogeneity without reference to normal controls
Abstract Background: Intratumor heterogeneity (ITH) is associated with tumor progression, unfavorable prognosis, immunosuppression, genomic instability, and therapeutic resistance. Thus, evaluation…
Modeling and analysis of site-specific mutations in cancer identifies known plus putative novel hotspots and bias due to contextual sequences
Keywords: Hotspots, Beta-Binomial, Recurrent mutations, Cancer, Algorithm, Simulations Authors: Victor Trevino License: © 2020 The Author CC BY-NC-ND 4.0 This…
Fast dimension reduction and integrative clustering of multi-omics data using low-rank approximation: application to cancer molecular classification
Abstract Background: One major goal of large-scale cancer omics study is to identify molecular subtypes for more accurate cancer diagnoses…