Cannabis tolerance reduces symptom relief
Abstract Objectives: We measure for the first time how tolerance from repeated consumption of medical cannabis affects acute symptom management.…
alcohol tolerance
Assessment of the associative determinants of tolerance to the effects of cannabis extract on exploratory behavior in rats
Abstract Experimental evaluation of cannabis tolerance has lacked an associative learning approach, focusing primarily on physiological variables. The present study…
Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain
Abstract Cannabigerol (CBG), derived from the cannabis plant, acts as an acute analgesic in a model of cisplatin-induced peripheral neuropathy…
Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats
Abstract The study aimed to explore in vivo the influence of cannabidiol (CBD) on the development of alcohol tolerance in…
Effect Compartment Model for the Evaluation of Tolerance to Psychological Highness Following Smoking Marijuana
Abstract The purpose of this study is to evaluate the development of tolerance, using a population modeling approach, in recreational…
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors
Abstract Background and Purpose: Src homology 3‐domain growth factor receptor‐bound 2‐like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB1…
Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users
Abstract Cannabis is the most commonly used illicit drug in the world. However, because of a changing legal landscape and…
Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain
Abstract The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the treatment of pain; yet, they…