Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress
Abstract The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent…
Advanced cancer
Experiences and Comfort of Young Cancer Patients Discussing Cannabis with Their Providers: Insights from a Survey at an NCI-Designated Cancer Center
Abstract Cannabis use among cancer patients for managing treatment-related symptoms is increasing, yet little is known about patterns in patient-provider…
Factors Affecting the Decision on Cannabis Use in Gynecologic Cancer Patients After the Legalization of Cannabis
Abstract Objective: To characterize the patterns of cannabis use among gynecologic cancer patients, in terms of potential factors influencing their…
Anti-Cancer and Anti-Proliferative Potential of Cannabidiol: A Cellular and Molecular Perspective
Abstract Cannabinoids, the bioactive compounds found in Cannabis sativa, have been used for medicinal purposes for centuries, with early discoveries…
Inflammation and cancer: friend or foe?
Abstract Chronic inflammation plays a crucial role in the onset and progression of pathologies like neurodegenerative and cardiovascular diseases, diabetes,…
Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions
Abstract Simple Summary: Cancer cachexia (CC) is a complex syndrome requiring a multimodal approach. Although a universally accepted definition and…
Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series
Abstract The use of patient‐reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients’ self‐report on…
Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model
Abstract Human pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and lethal tumor of the exocrine pancreas. Cannabinoids extracted from…
Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation
Abstract To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB1) and 2 (CB2)…
Self-reported knowledge of tetrahydrocannabinol and cannabidiol concentration in cannabis products among cancer patients and survivors
Abstract Purpose: Cannabis use may introduce risks and/or benefits among people living with cancer, depending on product type, composition, and…