Gaps in evidence for the use of medically authorized cannabis: Ontario and Alberta, Canada
Abstract Background: With legal access to medical cannabis in Canada since 2001, there is a need to fully characterize its…
Advanced cancer
Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders
Abstract In humans, various sites like cannabinoid receptors (CBR) having a binding affinity with cannabinoids are distributed on the surface…
A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation
Abstract Antiproliferative BTG/Tob proteins interact directly with the CAF1 deadenylase subunit of the CCR4-NOT complex. This binding requires the presence…
A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors
Abstract Background: Understanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent…
The Interplay between the Immune and the Endocannabinoid Systems in Cancer
Abstract The therapeutic potential of Cannabis sativa has been recognized since ancient times. Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two…
RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer
Abstract Background: Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors…
Bioinformatics and survival analysis of glia maturation factor-γ in pan-cancers
Abstract Background: Glia maturation factor-γ (GMFG) is reported to inhibit the actin nucleation through binding to the actin-related protein-2/3 complex…
The Prognostic Value of PERK in Cancer and Its Relationship With Immune Cell Infiltration
Abstract Background: Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a type I transmembrane protein that functions as an…
Molecular Mechanism of Cannabinoids in Cancer Progression
Abstract Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the…
Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System—Implications for Health and Disease
Abstract The endocannabinoid system (ECS) employs a huge network of molecules (receptors, ligands, and enzymatic machinery molecules) whose interactions with…