ITGAV as a promising diagnostic, immunological, and prognostic biomarker in pan-cancer
Abstract Integrin αV (ITGAV) plays a key role in cell adhesion, migration, and immune regulation, and is implicated in tumor…
Advanced cancer
Analysis of the prognostic and immune role of MCM6 in pan-cancer and experimental validation in lung adenocarcinoma cells
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-13598-9. Article type: Research Article Keywords: MCM6, Pan-cancer, Prognosis,…
Transcriptional enhanced associate domain factor 1 regulates cortactin-binding protein 2 N-terminal-like to control cell apoptosis in thyroid cancer
Abstract Objective: Understanding the molecular mechanisms underlying papillary thyroid carcinoma (PTC) is crucial for identifying drug targets. This research aims…
Self-Normalizing Multi-Omics Neural Network for Pan-Cancer Prognostication
Abstract Prognostic markers such as overall survival (OS) and tertiary lymphoid structure (TLS) ratios, alongside diagnostic signatures like primary cancer-type…
Formulation and Functional Characterization of a Cannabidiol-Loaded Nanoemulsion in Canine Mammary Carcinoma Cells
Abstract Background/Objectives: Mammary carcinoma is a common disease in female dogs. Cannabidiol (CBD) can inhibit cell proliferation and induce apoptosis…
Pan-cancer analysis of UGGT1 in human tumors and experimental validation in breast cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-12619-x. Article type: Research Article Keywords: UGGT1, Cancer, Biomarker,…
Medicinal cannabis for symptom control in advanced cancer: a double-blind, placebo-controlled, randomised clinical trial of 1:1 tetrahydrocannabinol and cannabidiol
Abstract Purpose: Patients with cancer commonly access cannabis hoping to relieve their symptoms. This study assessed whether a 1:1 10…
Pan-Cancer Computational Analysis of RKIP (PEBP1) and LKB1 (STK11) Co-Expression Highlights Distinct Immunometabolic Dynamics and Therapeutic Responses Within the Tumor Microenvironment
Abstract RKIP and LKB1, encoded by PEBP1 and STK11, respectively, have emerged as key regulators of cancer pathophysiology. However, their…
ANTP-SmacN7 enhances radiosensitivity in TPC-1 cells through XIAP-mediated activation of apoptotic protein
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-11131-6. Article type: Research Article Keywords: PTC, ANTP-SmacN7, XIAP,…
Zwilch kinetochore protein affects the prognosis of cancer patients by participating in cell proliferation, enhancing cell communication, and reshaping the tumor microenvironment
Abstract Background: Zwilch Kinetochore Protein(ZWILCH) has been reported to prevent cells from prematurely exiting mitosis. However, the underlying mechanisms or…