Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes
Abstract Mutational processes in tumors create distinctive patterns of mutations, composed of neutral “passenger” mutations and oncogenic drivers that have…
Advanced cancer
Pan-cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors
Abstract Studies have shown that PCNA clamp associated factor (PCLAF) plays a paramount role in a variety of cancers; however,…
Nutritional and Exercise Interventions in Cancer-Related Cachexia: An Extensive Narrative Review
Abstract One of the common traits found in cancer patients is malnutrition and cachexia, which affects between 25% to 60%…
Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors
Abstract Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1) is believed to function as a tumor suppressor, while Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2)…
Pan-cancer analysis identifies BIRC5 as a prognostic biomarker
Abstract Background: The BIRC5 gene encodes for the Survivin protein, which is a member of the inhibitor of apoptosis family.…
Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities
Abstract Cancer is a complex family of diseases affecting millions of people worldwide. Gliomas are primary brain tumors that account…
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
Abstract Background: Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain…
Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review
Abstract Introduction: Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve…
Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?
Abstract Cannabinoids have been purported as having a wide range of therapeutic uses although currently, there is minimal evidence to…
Pan-cancer analysis of necroptosis-related gene signature for the identification of prognosis and immune significance
Abstract Background: Necroptosis is a novel programmed cell death mode independent on caspase. A number of studies have revealed that…