“In the light of evolution:” keratins as exceptional tumor biomarkers
Abstract Keratins (KRTs) are the intermediate filament-forming proteins of epithelial cells, classified, according to their physicochemical properties, into “soft” and…
Advanced cancer
Identification of potential LncRNAs as papillary thyroid carcinoma biomarkers based on integrated bioinformatics analysis using TCGA and RNA sequencing data
Abstract The roles and mechanisms of long non-coding RNAs (lncRNAs) in papillary thyroid cancer (PTC) remain elusive. We obtained RNA…
Molecules promoting circulating clusters of cancer cells suggest novel therapeutic targets for treatment of metastatic cancers
Abstract Treatment of metastatic disease remains among the most challenging tasks in oncology. One of the early events that predicts…
Oncogenic role and potential regulatory mechanism of fatty acid binding protein 5 based on a pan-cancer analysis
Abstract As one member of fatty acid binding proteins (FABPs), FABP5 makes a contribution in the occurrence and development of…
A comprehensive pan-cancer analysis unveiling the oncogenic effect of plant homeodomain finger protein 14 (PHF14) in human tumors
Abstract The plant homeodomain (PHD) finger refers to a protein motif that plays a key role in the recognition and…
Finding miRNA–RNA Network Biomarkers for Predicting Metastasis and Prognosis in Cancer
Abstract Despite remarkable progress in cancer research and treatment over the past decades, cancer ranks as a leading cause of…
Pan-Cancer Analysis Reveals Functional Similarity of Three lncRNAs across Multiple Tumors
Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators in many biological processes. The dysregulation of lncRNA expression has…
Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma
Abstract Background: Leukemia inhibitory factor (LIF) exhibits significant tumor-promoting function, while its cognate receptor (LIFR) is considered to act as…
Approved Nanomedicine against Diseases
Abstract Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one of the most…
Downregulation of Dystrophin Expression Occurs across Diverse Tumors, Correlates with the Age of Onset, Staging and Reduced Survival of Patients
Abstract Simple Summary: Mutations of the DMD gene, encoding dystrophins, cause Duchenne muscular dystrophy (DMD). We found that while DMD…