Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis
Abstract Previous research has demonstrated that ferredoxin 1 (FDX1) contributes to the accumulation of toxic lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and…
Advanced cancer
The value of EYA1/3/4 in clear cell renal cell carcinoma: a study from multiple databases
Abstract There is evidence from multiple studies that dysregulation of the Eyes Absent (EYA) protein plays multiple roles in many…
A pan-cancer analysis of the expression and molecular mechanism of DHX9 in human cancers
Abstract Finding new targets is necessary for understanding tumorigenesis and developing cancer therapeutics. DExH-box helicase 9 (DHX9) plays a central…
High expression of RNF31 is associated with tumor immune cell infiltration and leads to poor prognosis in liver hepatocellular carcinoma
Abstract Ring finger protein 31 (RNF31) has been found to play an important role in tumor immunity. However, the role…
Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer
Abstract Papillary carcinomas account for the largest proportion of thyroid cancers, with papillary thyroid carcinoma (PTC) being prone to early…
Oncogenic role of copper‑induced cell death‑associated protein DLD in human cancer: A pan‑cancer analysis and experimental verification
Abstract Copper ions can bind directly to lipoylated components of the tricarboxylic acid (TCA) cycle, triggering the aggregation of mitochondrial…
Systematic integration of protein-affecting mutations, gene fusions, and copy number alterations into a comprehensive somatic mutational profile
Abstract Somatic mutations occur as random genetic changes in genes through protein-affecting mutations (PAMs), gene fusions, or copy number alterations…
Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with immune evasion and poor outcome
Abstract In tumors, somatic mutations of the PTEN suppressor gene are associated with advanced disease, chemotherapy resistance, and poor survival.…
Therapeutic potential of TRPM8 channels in cancer treatment
Abstract Cancer is a multifactorial process associated with changes in signaling pathways leading to cell cycle variations and gene expression.…
Research on the oncogenic role of the house-keeping gene GAPDH in human tumors
Abstract Background: As an internal reference gene, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis. While increasing evidence suggests…