Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer
Abstract Background: Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays…
adoptive cellular immunotherapy
Immunotherapeutic Value of MAP1LC3C and Its Candidate FDA-Approved Drugs Identified by Pan-Cancer Analysis, Virtual Screening and Sensitivity Analysis
Abstract Background: The autophagy pathway within the tumour microenvironment can be regulated to inhibit or promote tumour development. In the…
Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer
Abstract IQ motif containing GTPase-activating protein 3 (IQGAP3) is a member of the Rho family of guanosine-5′-triphosphatases (GTPases). IQGAP3 plays…
A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma
Abstract Background: DNA polymerase delta 1 catalytic subunit (POLD1) plays a key role in DNA replication and damage repair. A…
Pan-Cancer Analysis Identified CD93 as a Valuable Biomarker for Predicting Patient Prognosis and Immunotherapy Response
Abstract Background: The rapid development of immunotherapy has significantly improved patient outcomes in recent years. CD93, a novel biomarker expressed…
GIMAP7 as a Potential Predictive Marker for Pan-Cancer Prognosis and Immunotherapy Efficacy
Abstract Background: GIMAP, a GTP enzyme of immune-related proteins, plays a crucial role in immune mechanisms. Investigating GIMAP7 expression in…
CD93 Correlates With Immune Infiltration and Impacts Patient Immunotherapy Efficacy: A Pan-Cancer Analysis
Abstract Background: The clinical implementation of immune-checkpoint inhibitors (ICIs) targeting CTLA4, PD-1, and PD-L1 has revolutionized the treatment of cancer.…
Guanylate-Binding Protein 1 as a Potential Predictor of Immunotherapy: A Pan-Cancer Analysis
Abstract Background: Mainstream application of cancer immunotherapy is hampered by the low response rate of most cancer patients. A novel…
FAM46C as a Potential Marker for Pan-Cancer Prognosis and Predicting Immunotherapeutic Efficacy
Abstract Background:FAM46C is a common mutated gene in tumours. A comprehensive understanding of the relationship between FAM46C expression and pan-cancer…
TSH-TSHR axis promotes tumor immune evasion
Abstract Background: Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune…