Pan-Cancer Study on Protein Kinase C Family as a Potential Biomarker for the Tumors Immune Landscape and the Response to Immunotherapy
Abstract The protein kinase C (PKC) family has been described with its role in some cancers, either as a promoter…
adoptive cellular immunotherapy
An Integrated Pan-Cancer Analysis of 33 Human Cancers Reveals the Potential Clinical Implications and Immunotherapeutic Value of C-X-C Motif Chemokine Ligand 13
Abstract Background: C-X-C Motif Chemokine Ligand 13 (CXCL13) plays a crucial part in the pathogenesis of numerous lymphoproliferative disorders, inflammatory…
Pan-cancer analysis of N4-acetylcytidine adaptor THUMPD1 as a predictor for prognosis and immunotherapy
Abstract Background: THUMPD1 is a specific RNA adaptor that assists acetylation of mRNA and production of N4-acetylcytidine (ac4C). However, it…
A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment
Abstract T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression.…
Leptin Receptor Overlapping Transcript (LEPROT) Is Associated with the Tumor Microenvironment and a Prognostic Predictor in Pan-Cancer
Abstract Background: Leptin receptor overlapping transcript (LEPROT) is reported to be involved in metabolism regulation and energy balance as well…
Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
Abstract Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing…
Pan-Cancer Analysis Reveals the Signature of TMC Family of Genes as a Promising Biomarker for Prognosis and Immunotherapeutic Response
Abstract Transmembrane Channel-like (TMC) genes are critical in the carcinogenesis, proliferation, and cell cycle of human cancers. However, the multi-omics…
The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy
Abstract Background: Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice.…
Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma
Abstract Background: MKI67 plays a vital role in the tumour microenvironment (TME) and congenital immunity. The present work focuses on…
Roles of HMGBs in Prognosis and Immunotherapy: A Pan-Cancer Analysis
Abstract Background: High mobility group box (HMGB) proteins are DNA chaperones involved in transcription, DNA repair, and genome stability. Extracellular…