Differential expression of HAVCR2 gene in pan-cancer: A potential biomarker for survival and immunotherapy
Abstract T-cell immunoglobulin mucin 3 (TIM-3) has emerged as a promising immune checkpoint target in cancer therapy. However, the profile…
adoptive cellular immunotherapy
PTBPs: An immunomodulatory-related prognostic biomarker in pan-cancer
Abstract Background: The polypyrimidine tract-binding protein (PTBP) nuclear ribonucleoprotein family of proteins, including PTBP1, PTBP2 and PTBP3, regulate the process…
The expression and significance of efferocytosis and immune checkpoint related molecules in pancancer samples and the correlation of their expression with anticancer drug sensitivity
Abstract Background: The efferocytosis-related molecules have been considered to be correlated with the resistance to cancer chemotherapy. The aim of…
Identification and verification of YBX3 and its regulatory gene HEIH as an oncogenic system: A multidimensional analysis in colon cancer
Abstract The novel gene YBX3 is important for regulating translation and RNA catabolism and encodes a protein with a highly…
CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer
Abstract Currently, breast cancer (BRCA) has become the most common cancer in the world, whose pathological mechanism is complex. Among…
The epiphany derived from T-cell–inflamed profiles: Pan-cancer characterization of CD8A as a biomarker spanning clinical relevance, cancer prognosis, immunosuppressive environment, and treatment responses
Abstract CD8A encodes the CD8 alpha chain of αβT cells, which has been proposed as a quantifiable indicator for the…
Pan-cancer analyses and molecular subtypes based on the cancer-associated fibroblast landscape and tumor microenvironment infiltration characterization reveal clinical outcome and immunotherapy response in epithelial ovarian cancer
Abstract Background: Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment (TME). These cells play a supportive role throughout…
Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer
Abstract Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the…
A Pan-Cancer Analysis Reveals CLEC5A as a Biomarker for Cancer Immunity and Prognosis
Abstract Background: CLEC5A is a member of the C-type lectin superfamily. It can activate macrophages and lead to a series…
CXCL11 Correlates with Immune Infiltration and Impacts Patient Immunotherapy Efficacy: A Pan-Cancer Analysis
Abstract Background: Immunotherapy has achieved great success in cancer. Nevertheless, many patients cannot benefit from immune checkpoint blockade therapy because…