Palmitoylethanolamide: A Natural Compound for Health Management
Abstract All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases,…
acute inflammation
Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved n-6/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity
Abstract The consumption of fatty acids has increased drastically, exceeding the nutritional requirements of an individual and leading to numerous…
Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from Cannabis sativa L. Promising Compounds?
Abstract Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids that are receiving renewed interest…
Protein Kinases Mediate Anti-Inflammatory Effects of Cannabidiol and Estradiol Against High Glucose in Cardiac Sodium Channels
Abstract Background: Cardiovascular anomalies are predisposing factors for diabetes-induced morbidity and mortality. Recently, we showed that high glucose induces changes…
Characterization of Subtype Selective Cannabinoid CB2 Receptor Agonists as Potential Anti-Inflammatory Agents
Abstract Activation of the CB2 receptor has been shown to have anti-inflammatory and antinociceptive effects without causing psychoactive effects. Previously,…
Palmitoylethanolamide and Its Biobehavioral Correlates in Autism Spectrum Disorder: A Systematic Review of Human and Animal Evidence
Abstract Autism spectrum disorder (ASD) pathophysiology is not completely understood; however, altered inflammatory response and glutamate signaling have been reported,…
Potential role of cannabidiol in Parkinson’s disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation
Abstract Parkinson’s disease (PD) is a major neurodegenerative disease (ND), presenting a progressive degeneration of the nervous system characterized by…
High and Mighty? Cannabinoids and the microbiome in pain
Abstract In this review, we will focus on the potential role of the endogenous cannabinoids in modulating microbiota-driven changes in…
Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation
Abstract Simple Summary: Pro-inflammatory cytokines are considered to be one of the most important mediators affecting the function of central…
The Immunopathology of COVID-19 and the Cannabis Paradigm
Abstract Coronavirus disease-19 caused by the novel RNA betacoronavirus SARS-CoV2 has first emerged in Wuhan, China in December 2019, and…