Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments
Abstract Dravet syndrome (DS) is an epileptic syndrome caused by mutations in the Scn1a gene encoding the α1 subunit of…
acute inflammation
Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages
Abstract Cannabis sativa is widely used for medical purposes and has anti-inflammatory activity. This study intended to examine the anti-inflammatory…
Effects of a CB2 Subtype Selective Agonist ABK5-1 on Cytokine Production in Microglia
Abstract Background and objectives: Neuroinflammation is closely associated with various diseases including neuropathic pain. Microglia are immune cells in the…
Cannabis in Gastroenterology: Watch Your Head! A Review of Use in Inflammatory Bowel Disease, Functional Gut Disorders, and Gut-Related Adverse Effects
Abstract Purpose of review: To review recent clinical evidence surrounding the use of cannabinoids and cannabis in gastrointestinal diseases, particularly…
Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation
Abstract (E)-β-caryophyllene (BCP) is a bicyclic sesquiterpene widely distributed in the plant kingdom, where it contributes a unique aroma to…
E‐cigarette or Vaping Product Use–Associated Lung Injury Produced in an Animal Model From Electronic Cigarette Vapor Exposure Without Tetrahydrocannabinol or Vitamin E Oil
Abstract E‐cigarette or vaping product use–associated lung injury was recognized in the United States in the summer of 2019 and…
Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection
Abstract Background: Brain atrophy and cognitive deficits persist among individuals with suppressed HIV disease. The impact of cannabis use is…
Self-reported cannabis use and biomarkers of inflammation among adults in the United States
Abstract Background: Cannabis is among the most frequently used substance in United States (U.S.). Studies evaluating the association between cannabis…
Pulmonary Toxicity and Inflammatory Response of Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI
Abstract Recently, there has been an outbreak of a condition named e-cigarette or vaping products-associated lung injury (EVALI). The primary…
Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes
Abstract Cannabinoid subtype 2 receptors (CB2Rs) are G protein‐coupled receptors (GPCRs) belonging to the endocannabinoid system, a complex network of…