FibrilPaint to determine the length of Tau amyloids in fluids
Abstract The Tau protein forms amyloid fibrils in diseases like Alzheimer’s. Development of Tau fibrils correlate with disease progression. Until…
3 repeat Tau
Cannabidiol as a multifaceted therapeutic agent: mitigating Alzheimer’s disease pathology and enhancing cognitive function
Abstract Background: Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis sativa, has garnered significant interest due to its non-psychoactive…
Sensitive detection and propagation of brain-derived tau assemblies in HEK293-based wild-type tau seeding assays
Abstract The assembly of tau into filaments defines tauopathies, a group of neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease…
Seeding activity of skin misfolded tau as a biomarker for tauopathies
Abstract Background: Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hyperphosphorylated tau protein in…
Tau protein profiling in tauopathies: a human brain study
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s13024-024-00741-9. Article type: Research Article Keywords: Tau, Tauopathies, Mass…
Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies
Abstract Background: Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically phosphorylated tau protein in…
Determinants of astrocytic pathology in stem cell models of primary tauopathies
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01655-1. Article type: Research Article Keywords: Astrocytes, Stem cells,…
Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies
Abstract Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD),…
Neuroimmune proteins can differentiate between tauopathies
Abstract Background: Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The…
Proline-Rich Region II (PRR2) Plays an Important Role in Tau–Glycan Interaction: An NMR Study
Abstract (1) Background: Prion-like transcellular spreading of tau pathology in Alzheimer’s disease (AD) is mediated by tau binding to the…