Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze
Abstract Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the…
212-2 self-administration mouse model
Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ9-tetrahydrocannabinol (THC)
Abstract Rats were trained under a progressive-ratio schedule of sucrose or corn oil reinforcement. A mathematical model of progressive-ratio schedule…
Cannabinoid CB1 Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats
Abstract Tinnitus has been suggested to arise from neuronal hyperactivity in auditory areas of the brain, and anti-epileptic drugs are…
Behavioral and Neurochemical Changes in Mesostriatal Dopaminergic Regions of the Rat after Chronic Administration of the Cannabinoid Receptor Agonist WIN55,212-2
Abstract Background: The endocannabinoid system interacts extensively with other neurotransmitter systems and has been implicated in a variety of functions,…
The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat
Abstract Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate the cannabinoid-induced dependence/withdrawal signs, but molecular mechanisms…
Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell
Abstract 2-Arachidonoylglycerol (2-AG) is the most potent endogenous ligand of brain cannabinoid CB1 receptors and is synthesized on demand from…
Microinjection of WIN55,212-2 as A Cannabinoid Agonist into The Basolateral Amygdala Induces Sensitization to Morphine in Rats
Abstract Introduction: Previous studies have shown that the basolateral amygdale (BLA) is rich of CB1 cannabinoid receptors and involved in…
Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats
Abstract The cannabinoid CB1 receptor system is involved in feeding behaviors and the CB1 receptor antagonist SR141716A is an effective…
Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future
Abstract Over the last decades, the endocannabinoid system has been implicated in a large variety of functions, including a crucial…
Critical appraisal of the potential use of cannabinoids in cancer management
Abstract Cannabinoids have been attracting a great deal of interest as potential anticancer agents. Originally derived from the plant Cannabis…