Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2
Abstract The role of cannabinoids in thrombosis remains controversial. In view of the primary importance of tissue factor (TF) in…
212-2 self-administration mouse model
Effects of various cannabinoid ligands on choice behaviour in a rat model of gambling
Abstract It is estimated that 0.6–1% of the population in the USA and Canada fulfil the Diagnostic and Statistical Manual…
Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
Abstract The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over…
Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on learning in female rats
Abstract The effects of hormone status and age on the development of tolerance to Δ9-THC were assessed in sham-operated (intact)…
Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze
Abstract Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the…
Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ9-tetrahydrocannabinol (THC)
Abstract Rats were trained under a progressive-ratio schedule of sucrose or corn oil reinforcement. A mathematical model of progressive-ratio schedule…
Cannabinoid CB1 Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats
Abstract Tinnitus has been suggested to arise from neuronal hyperactivity in auditory areas of the brain, and anti-epileptic drugs are…
Functional Properties of the Catalytic Domain of Mouse Acidic Mammalian Chitinase Expressed in Escherichia coli
Abstract Mouse acidic mammalian chitinase (AMCase) plays important physiological roles in defense and nutrition. AMCase is composed of an N-terminal…
Behavioral and Neurochemical Changes in Mesostriatal Dopaminergic Regions of the Rat after Chronic Administration of the Cannabinoid Receptor Agonist WIN55,212-2
Abstract Background: The endocannabinoid system interacts extensively with other neurotransmitter systems and has been implicated in a variety of functions,…
The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat
Abstract Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate the cannabinoid-induced dependence/withdrawal signs, but molecular mechanisms…