Medicinal cannabis products for the treatment of acute pain
Abstract For thousands of years, medicinal cannabis has been used for pain treatment, but its use for pain management is…
2-arachidonoylglycerol
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
Abstract The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants…
The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
Abstract Childhood absence epilepsy (CAE) is a non-convulsive seizure disorder primarily in children characterized by absence seizures. Absence seizures consist…
Cannabinoids for the Treatment of Dermatologic Conditions
Abstract In recent years, cannabinoid (CB) products have gained popularity among the public. The anti-inflammatory properties of CBs have piqued…
Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures
Abstract Research on endocannabinoid signaling has greatly advanced our understanding of how the excitability of neural circuits is controlled in…
New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence
Abstract Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity…
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
Abstract Post-Traumatic Stress Disorder (PTSD), characterized by re-experiencing, avoidance, negative affect, and impaired memory processing, may develop after traumatic events.…
Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis
Abstract The modulation of the endocannabinoid system (ECS) has shown positive results in animal models of multiple sclerosis (MS) and…
Targeting the endocannabinoid system for management of HIV-associated neuropathic pain: A systematic review
Abstract Human immunodeficiency virus (HIV) infection and antiretroviral therapy can independently induce HIV-associated neuropathic pain (HIV-NP). There is a dearth…
THC Regulates Tearing via Cannabinoid CB1 Receptors
Abstract Purpose: Aqueous deficiency dry eye (ADDE) is a chronic condition affecting millions, with symptoms ranging from a dry itchiness…