Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis
Abstract Is Cannabis a boon or bane? Cannabis sativa has long been a versatile crop for fiber extraction (industrial hemp),…
Science Article
Trends in Illicit Cannabis Potency based on the Analysis of Law Enforcement Seizures in the Southern Area of Rome
Abstract Cannabis remains the most illicitly produced and consumed substance worldwide, and the average trans-Δ9-tetrahydrocannabinol (THC) content in cannabis products…
Changes in plasma endocannabinoids concentrations correlate with 18F-FDG PET/MR uptake in brown adipocytes in humans
Abstract Introduction: Recent data suggest a possible role of endocannabinoids in the regulation of brown adipose tissue (BAT) activity. Those…
Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study
Abstract Background: Individuals with an Opioid Use Disorder (OUD) have increased rates of cannabis use in comparison to the general…
Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders
Abstract Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). It is also…
Molecular Mechanisms Underlying Potential Pathogen Resistance in Cannabis sativa
Abstract Cannabis (Cannabis sativa L.) is one of the earliest cultivated crops, valued for producing a broad spectrum of compounds…
Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
Abstract Phytocannabinoids, including the non-addictive cannabis component cannabidivarin (CBDV), have been reported to hold therapeutic potential in several neurodevelopmental disorders…
Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson’s Disease In Vitro Model
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and…
Combining noninvasive brain stimulation with behavioral pharmacology methods to study mechanisms of substance use disorder
Abstract Psychotropic drugs and transcranial magnetic stimulation (TMS) are effective for treating certain psychiatric conditions. Drugs and TMS have also…
The Skin and Natural Cannabinoids–Topical and Transdermal Applications
Abstract The chemical constituents of the Cannabis plant known as cannabinoids have been extensively researched for their potential therapeutic benefits.…