Cannabidiol and Tetrahydrocannabinol Use in Parkinson’s Disease: An Observational Pilot Study
Abstract Background: There is a need for more research examining the use of cannabis, tetrahydrocannabinol (THC), and cannabidiol (CBD) products…
Science Article
Social Stigma and Discrimination Toward People With Drug Addiction: A National Survey in Korea
Abstract Objective: This study aims to understand the attitudes, stigma, and discrimination of the general adult population toward drug addiction.…
Long-Term Treatment with Cannabidiol-Enriched Cannabis Extract Induces Synaptic Changes in the Adolescent Rat Hippocampus
Abstract The endocannabinoid system (eCS) is widely distributed in mammalian tissues and it is classically formed by cannabinoid receptors, endogenous…
PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice
Abstract Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that regulate gene expression. Δ9-tetrahydrocannabinol (Δ9-THC) is a PPARγ…
SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
Abstract In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially expressed in axons where it has a…
Melatonin enhances KCl salinity tolerance by maintaining K+ homeostasis in Malus hupehensis
Abstract Large amounts of potash fertilizer are often applied to apple (Malus domestica) orchards to enhance fruit quality and yields,…
Low Doses of β-Caryophyllene Reduced Clinical and Paraclinical Parameters of an Autoimmune Animal Model of Multiple Sclerosis: Investigating the Role of CB2 Receptors in Inflammation by Lymphocytes and Microglial
Abstract Multiple Sclerosis (MS) is a prevalent inflammatory disease in which the immune system plays an essential role in the…
Impulsivity and Alcohol Use during Pregnancy and Postpartum: Insights from Novel Methodological Approaches within the Context of the COVID-19 Pandemic
Abstract Impaired emotion regulation and impulsivity have been linked to substance use. This study evaluated the association between emotion regulation…
Cannabis- and Substance-Related Carcinogenesis in Europe: A Lagged Causal Inferential Panel Regression Study
Abstract Recent European data facilitate an epidemiological investigation of the controversial cannabis–cancer relationship. Of particular concern were prior findings associating…
Questioning the role of palmitoylethanolamide in psychosis: a systematic review of clinical and preclinical evidence
Abstract Introduction: The endocannabinoid (eCB) system disruption has been suggested to underpin the development of psychosis, fueling the search for…