FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites
Abstract FoxP3, the master regulator of Tregs, employs two DNA-binding modes to recognize diverse DNA sequences. It multimerizes on long…
Science Article
A comprehensive pan-cancer analysis of the prognostic role and immunotherapy efficacy evaluation of Glyoxalase 1
Abstract Background: Glyoxalase 1 (GLO1), an enzyme responsible for breaking down methylglyoxal (MG), is increasingly recognized as a tumor-promoting factor…
Effectiveness of the Beat the Kick intervention in addressing substance abuse among adults with mild intellectual disabilities in the Netherlands: study protocol for an open-label, multicenter, superiority randomized controlled trial
Abstract Background: People with mild intellectual disabilities (MID) are at elevated risk of substance-use problems. Beat the Kick is a…
Does the Biofloc System Affect Water Quality, Reproduction, and Hemato-Immunology of Penaeus vannamei During Broodstock Maturation?
Abstract This study evaluated the effects of biofloc technology (BFT) on water quality, reproduction, and hemato-immunological parameters of Penaeus vannamei…
AI literacy and competency in nursing education: preparing students and faculty members for an AI-enabled future-a systematic review and meta-analysis
Abstract Introduction: Artificial Intelligence (AI) has made its way into every dimension of human life, and its impact is significant…
Metabolic toxicity and neurological dysfunction in methylmalonic acidemia: from mechanisms to therapeutics
Abstract Methylmalonic acidemia (MMAemia) is an inborn error of organic acid metabolism characterized by the accumulation of toxic metabolites—including methylmalonic…
Design and Preclinical Evaluation of First 68Ga-Labeled Cathepsin D‑Targeted Radiotracers
Abstract Cathepsin D (CTSD), a lysosomal aspartic protease linked to cancer progression and poor patient outcomes, is underexplored as a…
MCRS1 is associated with immunosuppressive microenvironments in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes
Abstract Background: Pan-cancer analyses focused on the immunological significance and therapeutic potential of microspherule protein 1 (MCRS1) remain unreported. This…
Identification of ITGA2 as a methylation-regulated oncogene through a CeRNA network in papillary thyroid carcinoma
Abstract Objective: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. This study aimed to construct a competing endogenous…
Changes in patterns of use and perceptions of cannabis among students in Canada: A decade of data from the Canadian Student Alcohol and Drugs Survey
Abstract Introduction: The Canadian Student Alcohol and Drugs Survey is a biennial, repeat cross-sectional survey of grade 7–12 students in…