NCIVISION: A Siamese Neural Network for Molecular Similarity Prediction MEP and RDG Images
Abstract Artificial neural networks in drug discovery have shown remarkable potential in various areas, including molecular similarity assessment and virtual…
Science Article
Cannabinoid and cannabinoid related receptors in fibroblasts, inflammatory and endothelial cells of the equine hoof with and without laminitis: novel pharmacological target
Abstract Background: Evidence suggests that the endocannabinoid system (ECS) is crucial for regulating inflammation, cell proliferation and pain. The ECS…
Development and Characterization of a High-CBD Cannabis Extract Nanoemulsion for Oral Mucosal Delivery
Abstract The cannabidiol (CBD)-rich cannabis extract CAN296 shows anti-inflammatory and anticancer activity relevant to oral lichen planus (OLP), oral graft-versus-host…
FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites
Abstract FoxP3, the master regulator of Tregs, employs two DNA-binding modes to recognize diverse DNA sequences. It multimerizes on long…
A comprehensive pan-cancer analysis of the prognostic role and immunotherapy efficacy evaluation of Glyoxalase 1
Abstract Background: Glyoxalase 1 (GLO1), an enzyme responsible for breaking down methylglyoxal (MG), is increasingly recognized as a tumor-promoting factor…
Effectiveness of the Beat the Kick intervention in addressing substance abuse among adults with mild intellectual disabilities in the Netherlands: study protocol for an open-label, multicenter, superiority randomized controlled trial
Abstract Background: People with mild intellectual disabilities (MID) are at elevated risk of substance-use problems. Beat the Kick is a…
Does the Biofloc System Affect Water Quality, Reproduction, and Hemato-Immunology of Penaeus vannamei During Broodstock Maturation?
Abstract This study evaluated the effects of biofloc technology (BFT) on water quality, reproduction, and hemato-immunological parameters of Penaeus vannamei…
Cannabinoid receptor 2 affect the inflammatory response in periodontitis by regulating macrophage M1/M2 polarization
Abstract Objective: This study investigated the effect of cannabinoid receptor 2 (CB2R) on macrophage polarization and inflammatory severity in periodontitis,…
Molecular Modeling and Analysis of Cannabinoid and Cannabinoid-like Molecules Combining K-Means Clustering with Pearson Correlation and PCA
Abstract More recently, cannabinoid molecules have been widely studied for their potential to treat various diseases. We used a multidisciplinary…
Elemental Composition and Strontium Isotopic Ratio Analysis of Industrial Hemp (Cannabis sativa L.) for Textile Applications
Abstract Industrial hemp (Cannabis sativa L.) is increasingly valued as a sustainable raw material for textile applications, yet reliable analytical…