Metabolic Responses of Melanocytes and Melanoma Cells to UVA Radiation and Phytocannabinoids Exposure
Abstract Ultraviolet A (UVA) radiation disrupts the redox balance of melanocytes and may lead to the development of melanoma, highlighting…
Science Article
Selected Cannabinoids, Cannabimimetic Agents and Artemisia Combinations as Theoretical Adjunct Strategies Against COVID-19
Abstract COVID-19 has spurred much interest in complementary and alternative agents for therapeutic purposes having antiviral and immunomodulatory effects. In…
Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients
Abstract Background/Objectives: Chronic low back pain (CLBP) affects approximately 20% of the global population and is a leading cause of…
UK Medical Cannabis Registry: an updated analysis of clinical outcomes of medicinal cannabis therapy for hypermobility-associated chronic pain
Abstract Introduction/Objective: The primary aim of this study was to evaluate changes in pain-specific and general health-related quality of life…
A cannabis use Reddit dataset for aspect-based sentiment analysis
Abstract Using publicly accessible Reddit posts, we developed a manually annotated dataset for traditional and aspect-based sentiment analysis (ABSA) of…
Ureic clearance granule ameliorates chronic kidney disease by reshaping microbial dysbiosis via modulating bile acid metabolism
Abstract Background: Chronic kidney disease (CKD) is a highly prevalent global public health problem that inevitably leads to renal failure.…
Non-Psychoactive Cannabis Extract Disrupts Reinstatement and Reconsolidation in Cocaine-Induced Conditioned Place Preference in Mice
Abstract Highlights: What are the main findings? What are the implications of the main findings? Abstract: Background: Cocaine use disorder…
Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders
Abstract Endocannabinoids (eCBs) are lipid-derived neuromodulators that regulate numerous neurophysiological processes by modulating synaptic transmission. Synthesised on demand in response…
High-dose cannabidiol for chronic neuropathic pain associated with spinal cord injury: a randomised clinical trial
Abstract Background: Chronic neuropathic pain is common after spinal cord injury (SCI), yet current treatments have limited efficacy and significant…
Navigating dose-effect complexities and challenges in cannabinoid therapy for aging-related neurobiological changes
Abstract Growing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular…