Molecular Docking of Natural Compounds as DPP-4 Inhibitors in Type 2 Diabetes: A Comprehensive Review
Abstract Dipeptidyl peptidase-4 (DPP-4) is an established therapeutic target in the treatment of type 2 diabetes mellitus (T2DM), primarily due…
Science Article
Interpol review of forensic toxicology, 2023–2025
Authors: Stephen Chi-yuen Ip, Chun-wa Chan, Chun-wo Chan, Anlea Chu, Wai-wah Chung, Janesse Wing-sze Hui, Ka-Wai Ku, Wing-sze Lee, Kam-moon…
Thymol Chemotype Thymus vulgaris L. Hydrolate: Volatile Chemical Fraction Composition and Antimicrobial Activity Against Bacterial and Fungal Pathogens
Abstract The increasing prevalence of antimicrobial resistance necessitates the development of alternative antimicrobial agents derived from natural sources. This study…
Integrative Bioinformatics Analysis Reveals COL13A1 and COL23A1 as Potential Diagnostic and Prognostic Biomarkers in Thyroid Cancer
Abstract Introduction: Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular…
Rosa rubiginosa L. Extract Rich in Bioactive Phenolics Possess Potent Anti‐Inflammatory, Antioxidant, Photoprotective, and Antimicrobial Biofunctional Activities
Abstract The hydroethanolic Rosa rubiginosa extract is evaluated in vitro for antioxidant, anti‐inflammatory, antiplatelet, photoprotective, and antimicrobial activities. Rich in…
Deciphering Antidiabetic, Anti‐Inflammatory, and Anti‐Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation
Abstract Alzheimer’s disease (AD) is a disease associated with loss of brain cholinergic functions and a common cause of dementia.…
Pan-cancer multi-omic integration of Trop2 reveals biological determinants and translational implications for ADC therapy
Abstract Trop2–directed antibody-drug conjugates (ADCs) show activity across epithelial cancers, yet determinants of target expression in tumors and normal tissues…
Monoamine Oxidase and Cholinesterase Inhibition Profiles of Semicarbazone and Thiosemicarbazone Derivatives
Abstract Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for their inhibition of monoamine oxidases and cholinesterases. Most…
Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma–Jurkat T Cell Coculture Model: A Multi-Omics Analysis
Abstract Cannabidiol (CBD) is a nonpsychoactive cannabinoid with emerging anticancer and immunomodulatory properties; however, its systems-level mechanisms in tumor-associated immune…
Cannabigerol and Cannabichromene Induce Lung Cancer Cell Death and Apoptosis—Contribution of PPARα to Cannabigerol Effects
Abstract Cannabinoids are potential anticancer agents for the add-on treatment of malignant tumors. Here, the effects of the previously less-explored…