Enhancement drugs: are there limits to what we should enhance and why?
Abstract Substances, such as alcohol, opiates and cannabis, have been used by humans for millennia. Today, a much wider range…
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Cannabinoids for the Treatment of Schizophrenia? A Balanced Neurochemical Framework for Both Adverse and Therapeutic Effects of Cannabis Use
Abstract Recent studies have found that cannabinoids may improve neuropsychological performance, ameliorate negative symptoms, and have antipsychotic properties for a…
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
Abstract Background: ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific ErbB2-targeted…
Treatment of Irritability in Huntington’s Disease
Abstract Irritability is a common neuropsychiatric feature of Huntington’s disease (HD), with prevalences varying from 38% to 73%. Similar prevalences…
Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
Abstract Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol. It is well-known…
A retrospective analysis of cannabis use in a cohort of mentally ill patients in Sri Lanka and its implications on policy development
Abstract Background: Several epidemiological studies have shown that cannabis; the most widely used illegal drug in the world, is associated…
Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms
Abstract Cannabinoids are used clinically on a subacute basis as prophylactic agonist antiemetics for the prevention of nausea and vomiting…
Methamphetamine Use among Newly Diagnosed HIV-Positive Young Men in North Carolina, United States, from 2000 to 2005
Abstract Background: Methamphetamine (MA) is a new arrival to the Southeastern United States (US). Incidence of HIV is also increasing…
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
Abstract Background: Adult neurogenesis is a particular example of brain plasticity that is partially modulated by the endocannabinoid system. Whereas…
Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents
Abstract Rationale: Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial…