Cannabinoid Receptors as Target for Treatment of Osteoporosis: A Tale of Two Therapies
Abstract The central nervous system plays an important role in regulating bone metabolism in health and in disease with a…
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Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae
Abstract Monoacylglycerols (MAGs) are short-lived intermediates of glycerolipid metabolism. Specific molecular species, such as 2-arachidonoylglycerol, which is a potent activator…
CB2 Cannabinoid Receptor Targets Mitogenic Gi Protein–Cyclin D1 Axis in Osteoblasts
Abstract CB2 is a Gi protein–coupled receptor activated by endo- and phytocannabinoids, thus inhibiting stimulated adenylyl cyclase activity. CB2 is…
Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis
Abstract Cogent evidence shows that cannabis plays a variable role on behavioral regulation and the pathophysiology of most psychiatric conditions.…
Dendritic Cell Regulation by Cannabinoid-Based Drugs
Abstract Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models…
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Abstract Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in…
Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
Abstract The endocannabinoid system has been shown to be associated with neurodegenerative diseases and dementia. We review the preclinical and…
The Role of Cannabinoid Receptors in the Descending Modulation of Pain
Abstract The endogenous antinociceptive descending pathway represents a circuitry of the supraspinal central nervous system whose task is to counteract…
The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism
Abstract Phytocannabinoids present in Cannabis plants are well known to exert potent anti-inflammatory and immunomodulatory effects. Previously, we have demonstrated…
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes
Abstract Purpose: We have previously shown that non-psychotropic cannabidiol (CBD) protects retinal neurons in diabetic rats by inhibiting reactive oxygen…