Adolescent Brain Development and the Risk for Alcohol and Other Drug Problems
Abstract Dynamic changes in neurochemistry, fiber architecture, and tissue composition occur in the adolescent brain. The course of these maturational…
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Endocannabinoids and Schizophrenia
Abstract The endocannabinoids anandamide and 2-arachydonoylglycerol (2-AG) are lipids naturally derived from membrane precursors which bind cannabinoid receptors (CB1, CB2).…
Retrograde Endocannabinoid Signaling Reduces GABAergic Synaptic Transmission to Gonadotropin-Releasing Hormone Neurons
Abstract Cannabinoids suppress fertility via reducing hypothalamic GnRH output. γ-Aminobutyric acid (GABA)A receptor (GABAA-R)-mediated transmission is a major input to…
Acute effects of MDMA (3,4-methylenedioxymethamphetamine) on EEG oscillations: alone and in combination with ethanol or THC (delta-9-tetrahydrocannabinol)
Abstract Rationale: Typical users of 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) are polydrug users, combining MDMA with alcohol or cannabis [most active…
A collaborative community approach to adolescent substance misuse in Iceland
Abstract Substance use has become a major threat to health and human development in many European countries. In 23 out…
Risky Decisions and Their Consequences: Neural Processing by Boys with Antisocial Substance Disorder
Abstract Background: Adolescents with conduct and substance problems (“Antisocial Substance Disorder” (ASD)) repeatedly engage in risky antisocial and drug-using behaviors.…
Tissue Engineering of Cartilage; Can Cannabinoids Help?
Abstract This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the…
Investigational pharmacology for low back pain
Abstract Study design: Review and reinterpretation of existing literature. Objective: This review article summarizes the anatomy and pathogenesis of disease…
Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting
Abstract Chemotherapy-induced nausea and vomiting (CINV) is a complex pathophysiological condition and consists of two phases. The conventional CINV neurotransmitter…
From Fertilisation to Implantation in Mammalian Pregnancy—Modulation of Early Human Reproduction by the Endocannabinoid System
Abstract There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The…