A molecular taxonomy of tumors independent of tissue-of-origin
Abstract Cancer is an organism-level disease, impacting processes from cellular metabolism and the microenvironment to systemic immune response. Nevertheless, efforts…
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Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update
Abstract Chronic neuropathic pain (CNP) is a disabling medical condition that impairs the health-related quality-of-life of affected patients. A high…
Psychotropics and COVID-19: An analysis of safety and prophylaxis
Abstract The use of psychotropics during the COVID-19 pandemic has raised two questions, in order of importance: first, what changes…
A pan-cancer analysis of the expression of gasdermin genes in tumors and their relationship with the immune microenvironment
Abstract Background: Gasdermins (GSDMs) are a class of proteins related to pyrolysis and in humans, consist of GSDMA, GSDMB, GSDMC,…
Pan-cancer analysis of CXCR4 carcinogenesis in human tumors
Abstract Background: C-X-C chemokine receptor 4 (CXCR4) is a specific receptor of stromal cell-derived factor-1, also known as CXCL12. The…
The impacts of COVID-19 on older adults’ active transportation mode usage in Isfahan, Iran
Abstract Aims: Since active mobility is essential for older adults’ health and well-being, especially in crises, this study aims to…
Anxiety, depression-like behaviors and biochemistry disorders induced by cannabis extract in female mice
Abstract Cannabis is an annual herbaceous plant sometimes grown for decoration and used as bird food that looks like flax.…
A pan-cancer study of PD-1 and CTLA-4 as therapeutic targets
Abstract Background: Immunotherapy is a new and powerful weapon against tumors, represented by inhibitors of programmed death-1 (PD-1) and cytotoxic…
CCR4 is a prognostic biomarker and correlated with immune infiltrates in head and neck squamous cell carcinoma
Abstract Background: Increased evidence has indicated that the tumour microenvironment plays an essential in the development, treatment and prognosis of…
Changes in Healthcare Resource Use and Costs in Commercially Insured Insomnia Patients Initiating Suvorexant
Abstract Introduction: Insomnia diagnosis has been associated with a significant clinical and economic burden on patients and healthcare systems. This…