Cannabis smoke suppresses antiviral immune responses to influenza A in mice
Abstract Rationale: Despite its increasingly widespread use, little is known about the impact of cannabis smoking on the response to…
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Tolerability of long‐term cannabidiol supplementation to healthy adult dogs
Abstract Background: Cannabidiol (CBD) has therapeutic potential in companion animals. Shorter‐term studies have determined that CBD is well tolerated in…
IUPHAR review- Preclinical models of neuropathic pain: Evaluating multifunctional properties of natural cannabinoid receptors ligands
Abstract Neuropathic pain remains prevalent and challenging to manage and is often comorbid with depression and anxiety. The new approach…
Computational exploration of the significance of COPS6 in cancer: Functional and clinical relevance across tumor types
Abstract BACKGROUND: The COP9 signalosome subunit 6 (COPS6) has been implicated in cancer progression, while its precise role in most…
Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer
Abstract Background: Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer (PCa), the long…
Pan-Cancer Analysis and Validation of Opioid-Related Receptors Reveals the Immunotherapeutic Value of Toll-Like Receptor 4
Abstract Introduction: The relationship between the expression of opioid-associated receptors and cancer outcomes is complex and varies among studies. Methods:…
The association between cannabis vaping and other substance use
Abstract Around a third of past 12-month cannabis users report cannabis vaping. Proportion of cannabis vapers is higher among younger…
Advancing biological investigations using portable sensors for detection of sensitive samples
Abstract Portable biosensors are emerged as powerful diagnostic tools for analyzing intricately complex biological samples. These biosensors offer sensitive detection…
KLRB1 is a novel prognostic biomarker in endometrial cancer and is associated with immune infiltration
Abstract Background: Endometrial cancer (EC) has the characteristics of high mortality and poor prognosis in the advanced stage, which seriously…
An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
Abstract The clinical utility of human interleukin-2 (hIL-2) is limited by its short serum half-life, preferential activation of regulatory T…