Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer

Abstract Background: Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer (PCa), the long tail of cancer genes remains to be defined. Goosecoid (GSC) has been implicated in cancer development. However, the comprehensive biological role of GSC in pan-cancer, specifically in PCa, remains unexplored. The aim of this study was to investigate the role of GSC in PCa development. Methods: We performed a systematic bioinformatics exploration of GSC using datasets from The Cancer Genome