Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers
Abstract Background: Cancer is a complex disease that is the second leading cause of death in the United States. Despite…
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On the role of functional groups in the formation of diazonium based covalent attachments: dendritic vs. layer-by-layer growth†
Abstract Multilayered growth is often observed upon electrografting aryl diazonium derivatives on graphitic substrates due to the reactive nature of…
An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma
Abstract Esophageal squamous cell carcinoma (ESCC), one of the most lethal cancers, has become a global health issue. Stearoyl-coA desaturase…
Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: A pilot study
Abstract Background: Individuals with schizophrenia are at elevated genetic risks for comorbid cannabis use, and often experience exacerbations of cognitive…
Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies
Abstract Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body.…
Simultaneous Determination of Posaconazole and Hemp Seed Oil in Nanomicelles through RP-HPLC via a Quality-by-Design Approach
Abstract The present study involves the development of a reverse-phase HPLC method employing the quality-by-design methodology for the estimation of…
A Retrospective Study on the Three-Port Technique of Laparoscopic Common Bile Duct Exploration for the Management of Cholelithiasis and Choledocholithiasis
Abstract Background: Laparoscopic cholecystectomy (LC) with laparoscopic common bile duct exploration (LCBDE) is convenient in treating cholelithiasis and choledocholithiasis due…
Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer
Abstract Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms…
Bio-Psycho-Social Profile of People with Substance Use Disorders Treated in Locally Assigned Treatment Facilities in Kandahar, Afghanistan
Abstract Background: Substance use and its associated bio-psycho-social problems are public health concerns with harmful individual and social consequences. Objective:…
Cannabinoids in the treatment of cancer anorexia and cachexia: Where have we been, where are we going?
Abstract Cachexia–anorexia cancer syndrome remains an unmet clinical need with a dearth of treatment and no standard of care. Acting…