SUGT1 regulates the progression of ovarian cancer through the AKT/PI3K/mTOR signaling pathway
Abstract Macroscopic analysis of SUGT1 and cancer prognosis. ELF1 stimulates the transcription of SUGT1 through the PI3K/AKT pathway. SUGT1 promote…
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Seasonal variations in psychiatry outpatient service utilization in a tertiary health care center in subtropical arid regions of northwestern India
Abstract Background: Research on climatic parameters contributing to psychiatric disorder seasonality is limited, particularly in subtropical, arid climates like Rajasthan,…
Scupa: Single-cell unified polarization assessment of immune cells using the single-cell foundation model
Abstract Immune cells undergo cytokine-driven polarization in respond to diverse stimuli. This process significantly modulates their transcriptional profiles and functional…
Outcomes after open repair of aortic aneurysms and dissections in cannabis consumers
Abstract Objective: To investigate the influence of cannabis consumption on the mid- and long-term surgical outcomes of patients with aortic…
Cannabidiol attenuates arsenic-induced nephrotoxicity via the NOX4 and NF-κB pathways in mice
Abstract Background and purpose: Cannabidiol (CBD) is a phenolic terpene compound with anticancer, antioxidant, anti-inflammatory, antibacterial, neuroprotective, and anticonvulsant properties.…
Ten-year cardiovascular disease risk and related factors in lifetime marijuana use with comorbid methamphetamine-associated psychotic disorder: a QRISK®3 study
Abstract Background: Methamphetamine use and related direct and indirect problems are increasing all over the world. The coexistence of lifetime…
Acute care of cyclic vomiting syndrome and cannabinoid hyperemesis syndrome in the home and emergency department
Abstract Background: Cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome (CHS) are both characterized by episodic, acute transitions from asymptomatic…
Elucidating the pan-oncologic landscape of S100A9: prognostic and therapeutic corollaries from an integrative bioinformatics and Mendelian randomization analysis
Abstract The calcium-binding protein S100A9 has emerged as a pivotal biomolecular actor in oncology, implicated in numerous malignancies. This comprehensive…
E-cigarette market share by nicotine claims
Abstract Background: Nicotine forms (salt vs. freebase) and isomers (synthetic vs. tobacco-derived) are key characteristics of e-cigarettes that manufacturers manipulate,…
Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response
Abstract Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major transcription factor that functions in maintaining redox homeostasis in…