Abstract Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI)…
Abstract The basic mechanism of the major neurodegenerative diseases, including neurogenic pain, needs to be agreed upon before rational treatments…
Abstract Rationale: Anecdotally, both acute and chronic cannabis use have been associated with apathy, amotivation, and other reward processing deficits.…
Abstract Background: Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the…
Abstract Cannabis is classified as a schedule I controlled substance by the US Drug Enforcement Agency, meaning that it has…
Abstract G protein-coupled receptors (GPCRs) transduce external chemical cues into intracellular signals and are involved in a plethora of physiological…
Abstract Since 24 states and the District of Columbia have legalized marijuana in some form, suppliers of legal marijuana have…
Abstract Electronic supplementary material: The online version of this article (doi:10.1186/s13041-016-0259-6) contains supplementary material, which is available to authorized users.…
Abstract Background: With the non-medical use of prescription opioids increasingly becoming a method of abuse in Canada, the number of…
Abstract Rationale: The appetite-stimulating properties of cannabis are well documented and have been predominantly attributed to the hyperphagic activity of…