The grass isn’t always greener: The effects of cannabis on embryological development
Abstract With the increasing publicity of marijuana due to recent legislation, it is pertinent that the effects of fetal exposure…
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Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats
Abstract Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson’s…
Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice
Abstract Aims/hypothesis: Abnormal cannabidiol (Abn-CBD) and AS-1269574 are potent selective agonists for GPR55 and GPR119, respectively. The present study evaluated…
Endocannabinoid signaling in social functioning: an RDoC perspective
Abstract Core deficits in social functioning are associated with various neuropsychiatric and neurodevelopmental disorders, yet biomarker identification and the development…
Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid
Abstract Autism spectrum disorders (ASD) are characterized by altered sociability, compromised communication and stereotyped/repetitive behaviors, for which no specific treatments…
Comparison of illegal drug use pattern in Taiwan and Korea from 2006 to 2014
Abstract Background: Illegal drug use has long been a global concern. Taiwan and Korea are geographically adjacent and both countries…
Tracking Dabbing Using Search Query Surveillance: A Case Study in the United States
Abstract Background: Dabbing is an emerging method of marijuana ingestion. However, little is known about dabbing owing to limited surveillance…
Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs
Abstract Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role…
Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues
Abstract This overview covers a wide range of cannabis topics, initially examining issues in dispensaries and self-administration, plus regulatory requirements…
Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders
Abstract Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs), namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions…