Metabolomic analysis of methyl jasmonate treatment on phytocannabinoid production in Cannabis sativa
Abstract Cannabis sativa is a multi-use and chemically complex plant which is utilized for food, fiber, and medicine. Plants produce…
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Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
Abstract The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission tomography (PET) imaging was intensively explored. To…
Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report
Abstract Background: Delta-8 tetrahydrocannabinol (THC) is a psychoactive cannabinoid from the cannabis plant that can be synthetically converted from cannabidiol…
The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis
Abstract Cannabidiol (CBD) is the main active ingredient in the cannabis plant used for treating epilepsy and related diseases. However,…
An Individuality of Response to Cannabinoids: Challenges in Safety and Efficacy of Cannabis Products
Abstract Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD),…
Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence
Abstract Objective: To review and synthesise the global evidence regarding the health effects of electronic cigarettes (e‐cigarettes, vapes). Study design:…
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds
Abstract Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20%…
Non‐interventional, prospective, observational study on spasticity‐associated symptom control with nabiximols as add‐on therapy in patients with multiple sclerosis spasticity in Austria
Abstract Background and purpose: Randomized controlled trials and observational studies of nabiximols oromucosal spray in patients with multiple sclerosis (MS)…
Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats
Abstract Rationale: The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or…
Biosynthesis of Phytocannabinoids and Structural Insights: A Review
Abstract Cannabis belongs to the family Cannabaceae, and phytocannabinoids are produced by the Cannabis sativa L. plant. A long-standing debate…