Looking Back, Moving Forward in Pain Medicine
Abstract Pain is an ancient medical complaint and a clinical riddle that has never been entirely solved. Looking back into…
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Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–aging and epigenomics
Abstract Much recent attention has been directed toward the spatial organization of the cell nucleus and the manner in which…
Vogt–Koyanagi–Harada disease with a unilateral presentation in a patient with marijuana overuse: Role of multimodal imaging in suspected patients
Abstract Key Clinical Message: Harada disease could uniquely present with only unilateral symptoms, as was seen in our patient. However,…
Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs
Abstract Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam and in late 2021 arose on the…
The role of microorganisms in the biotransformation of psychoactive substances and its forensic relevance: a critical interdisciplinary review
Abstract : Microorganisms are widespread on the planet being able to adapt, persist, and grow in diverse environments, either rich…
Co-Dispersion Delivery Systems with Solubilizing Carriers Improving the Solubility and Permeability of Cannabinoids (Cannabidiol, Cannabidiolic Acid, and Cannabichromene) from Cannabis sativa (Henola Variety) Inflorescences
Abstract Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges…
Pharmacological Evaluation of Newly Synthesized Cannabidiol Derivates on H9c2 Cells
Abstract Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid that can be found in Cannabis sativa and possesses numerous pharmacological effects. Due…
Update on Cannabidiol Clinical Toxicity and Adverse Effects: A Systematic Review
Abstract Background: Compelling evidence from preclinical and clinical studies supports the therapeutic role of cannabidiol (CBD) in several medical disorders.…
Obstructive sleep apnea phenotypes eligible for pharmacological treatment
Abstract Obstructive sleep apnea (OSA) is a common disorder. Its prevalence is increasing worldwide, partially due to increasing rates of…
The development of a Cannabis Knowledge Assessment Tool (CKAT)
Abstract Background: Misconceptions about the health risks of cannabis remain prevalent, indicating the need to improve public health messaging and…