Natural Product-Inspired Dopamine Receptor Ligands
Abstract Due to their evolutionary bias as ligands for biologically relevant drug targets, natural products offer a unique opportunity as…
Free
Epigenetic modification of PHLDA2 is associated with tumor microenvironment and unfavorable outcome of immune checkpoint inhibitor-based therapies in clear cell renal cell carcinoma
Abstract Background: A substantial proportion of patients with metastatic clear cell renal cell carcinoma (ccRCC) cannot derive benefit from immune…
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Abstract Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and…
Tunable Hydrogen-Related Defects in ZnO Nanowires Using Oxygen Plasma Treatment by Ion Energy Adjustment
Abstract The chemical bath deposition (CBD) process enables the deposition of ZnO nanowires (NWs) on various substrates with customizable morphology.…
Endoscopic Characterization of Giant Choledocholithiasis and Its Correlation With Primary Choledocholithiasis
Abstract Introduction: Gallstone disease is extremely prevalent in Western society, and the prevalence of common bile duct (CBD) stones with…
Tau protein profiling in tauopathies: a human brain study
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s13024-024-00741-9. Article type: Research Article Keywords: Tau, Tauopathies, Mass…
Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer
Abstract Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth and survival. However, the mechanisms underlying the formation…
Safety climate in the operating room in the pre-pandemic and pandemic period of COVID-19: A mixed method study
Abstract Introduction: To verify whether the COVID-19 pandemic has had an impact on the safety climate based on the perception…
RAB42 overexpression correlates with poor prognosis, immune cell infiltration and chemoresistance
Abstract Background: RAB42 (Ras-related protein 42) is a new small GTPase that controls the vesicular trafficking from endosomes to trans-Golgi…
Comprehensive analysis of PHF5A as a potential prognostic biomarker and therapeutic target across cancers and in hepatocellular carcinoma
Abstract Objective: Cancer is a predominant cause of death globally. PHD-finger domain protein 5 A (PHF5A) has been reported to…