Integrative analysis identifies TEAD4 as a universal prognostic biomarker in human cancers
Abstract Introduction: TEA domain transcription factor 4 (TEAD4), a key effector of the Hippo signaling pathway, has been increasingly associated…
Free
Rural inpatient hospitals and substance use—a 10-year retrospective analysis
Abstract Aim: To determine the burden and nature of substance use presentations within a defined rural region and provide an…
Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial
Abstract Chronic low back pain (CLBP) affects over half a billion people worldwide. Current pharmacologic treatments offer limited efficacy and…
A remote measurement study of PTSD and cannabis use among veterans: Recruitment, retention, and data availability
Abstract With the growing availability of cannabis and increasing public support for legalization, cannabis use disorder (CUD) rates have risen,…
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer’s Disease Management
Abstract Neurodegenerative disorders, including Alzheimer’s disease (AD), impose a significant burden on society due to their progressive nature and the…
New insights into the crosstalk between endocannabinoids and sphingosine-1-phosphate
Abstract This review aims at highlighting the interplay between the endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol and sphingosine-1-phosphate (S1P) signaling. The…
Global Influence of Cannabis Legalization on Social Media Discourse: Mixed Methods Study
Abstract Background: Cannabis is the third most consumed drug worldwide, with its use linked to a high number of substance…
Pollenkitt From Narcissus tazetta: Evaluation of Its UV‐Protective Potential as a Plant‐Based Biomaterial Source
Abstract Pollenkitt, the lipid‐rich coating of pollen grains, is a promising natural ultraviolet (UV)‐protective source rich in phenolic and flavonoid…
ABCB1 polymorphisms are associated with clinical response to nabiximols in patients with multiple sclerosis-related spasticity
Keywords: Multiple sclerosis, Single nucleotide polymorphisms, Nabiximols, Spasticity, ABCB1 Authors: Alessandra Gemma, Marco Mauri, Paola Banfi, Maurizio Versino, Alen Zollo,…
A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis
Abstract Nuclear receptor farnesoid X receptor (FXR) acts as a key regulator of bile acid pool homeostasis and metabolism. Within…