DEP domain containing 1: a potential oncogenic driver
Abstract Background: DEP domain-containing protein 1 (DEPDC1) is essential for cell cycle regulation and is increasingly associated with multiple cancers.…
Free
AutoTFCNNY: A multi-instance neural network for enhanced early cancer detection using TCR data
Abstract For most cancers, early diagnosis and intervention can significantly improve cure rates and patient survival. Consequently, achieving early and…
GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner
Abstract Background: Thyroid cancer, the most prevalent endocrine malignancy, poses significant therapeutic challenges due to its heterogeneous biological behavior. Growth…
In Search of Molecular Correlates of Fibromyalgia: The Quest for Objective Diagnosis and Effective Treatments
Abstract Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, non-restorative sleep, and cognitive impairment. Its pathogenesis reflects…
Preoperative coronal imbalance in degenerative scoliosis: a study on coronal and sagittal spinal-pelvic parameters——a retrospective study
Abstract Objective: To investigate the relationship between spinal-pelvic parameters in the coronal and sagittal planes and preoperative coronal imbalance (CIB)…
Sustainable slag-based geopolymers incorporating styrofoam and Moringa leaves ash for mechanical enhancement and crystal violet adsorption
Abstract Synthetic dye contamination poses a significant threat to water resources, necessitating the development of efficient removal technologies. This study…
BRPF1 in cancer epigenetics: a key regulator of histone acetylation and a promising therapeutic target
Abstract Bromodomain and PHD finger-containing protein 1 (BRPF1) is an essential component of histone acetyltransferase complexes, where it acts as…
CORO1A: a pan-cancer prognosis, diagnostic and immune biomarker based on breast cancer validation
Abstract Introduction: CORO1A, a constituent of the Coronins family, is a conserved protein throughout evolution that interacts with actin within…
Importance of PERK pathway modulation on colorectal cancer management: a systematic review
Abstract Background: The protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the Unfolded Protein Response (UPR) plays a complex…
Natural Products Inhibit Bacterial Growth and Modulate Quorum‐Sensing Systems Las and Rhl in Pseudomonas aeruginosa PA14
Abstract Quorum sensing (QS) is a bacterial cell communication system in Pseudomonas aeruginosa, which regulates the production of several virulence…