Effects of a Cannabinoid-Based Phytocomplex (Pain ReliefTM) on Chronic Pain in Osteoarthritic Dogs
Abstract Chronic pain is one of the most disabling conditions in dogs, as it affects various aspects of a dog’s…
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Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms
Abstract Plant secondary metabolites (PSMs) are a diverse group of bioactive compounds, including flavonoids, polyphenols, saponins, and terpenoids, which have…
Hypothesized pharmacogenomic and medication influences on tetrahydrocannabinol and cannabidiol metabolism in a cohort of unselected oral cannabis users
Abstract Background: Differences in cannabinoid metabolism and patient responses can arise even with equivalent doses and formulations. Genetic polymorphisms in…
Novel Selective Cardiac Myosin-Targeted Inhibitors Alleviate Myocardial Ischaemia–Reperfusion Injury
Abstract Purpose: Reperfusion of the ischaemic heart is essential to limit myocardial infarction. However, reperfusion can cause cardiomyocyte hypercontracture. Recently,…
Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology
Abstract Background and objective: Non-motor symptoms frequently develop throughout the disease course of Parkinson’s disease (PD), and pose affected individuals…
Identification of hub genes and potential molecular mechanisms related to radiotherapy in thyroid cancer
Abstract Radiotherapy is a common approach during the treatment of thyroid cancer (THCA). It is urgent to identify the radiotherapy-related…
Plant‐Derived Treatments for Different Types of Muscle Atrophy
Abstract With the development of medicine and chemistry, an increasing number of plant‐derived medicines have been shown to exert beneficial…
Metal Ion Signaling in Biomedicine
Abstract Complex multicellular organisms are composed of distinct tissues involving specialized cells that can perform specific functions, making such life…
Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
Abstract The discovery by cryo-electron microscopy (cryo-EM) that the neu-ropathological hallmarks of different tauopathies, including Alzheimer’s disease, corticobasal degeneration (CBD),…
In Web We Trust: The Promised Cannabidiol Effects on Obesity as a Matter of Language and Marketing on Webpages
Abstract Background: Today more and more people search the web for health-related information, risking to come across misinformation and biased…