Cannabinoid receptor deficiencies drive immune response dynamics in Salmonella infection
Abstract This study investigated the roles of cannabinoid receptors 1 and 2 (CB1R and CB2R) in regulating host responses to…
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High-Pressure Dielectric Spectroscopic Studies of Amorphous CBD: Investigating Molecular Dynamics and Physical Stability Under Manufacturing Conditions of the Pharmaceuticals
Abstract Objectives: This study highlighted the key role played by high-pressure (HP) dielectric spectroscopic measurements of amorphous CBD to probe…
Laparoscopic Transcystic SpyGlass Discover-Assisted Common Bile Duct Exploration and Clearance: An Efficient and Cost-Effective Alternative for Common Bile Duct Stone Management
Abstract Aim This study aimed to assess the safety and efficacy of laparoscopic transcystic SpyGlass Discover (Boston Scientific Corporation, Marlborough,…
Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-92844-6. Article type: Research Article Keywords: Cannabis, Maternal, Omega-3…
The Importance of Accurate Drug Use History in Diagnosing and Managing Cannabinoid Hyperemesis Syndrome: A Case Report
Abstract Cannabinoid hyperemesis syndrome (CHS) is a paradoxical condition characterized by recurrent episodes of nausea, vomiting, and abdominal pain in…
Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series
Abstract Background: In patients receiving anti‐cancer treatment, cachexia results in poorer oncological outcomes. However, there is limited understanding and no…
The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy
Abstract Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in…
Cannabis use and suicide in people with a diagnosis of schizophrenia: a systematic review and meta-analysis of longitudinal, case control, and cross-sectional studies
Abstract Cannabis use is highly prevalent in people with schizophrenia and is related to adverse clinical outcomes, including relapse and…
Cannabinoids Activate Endoplasmic Reticulum Stress Response and Promote the Death of Avian Retinal Müller Cells in Culture
Abstract Background/Objectives: Activation of cannabinoid CB1 or CB2 receptors induces the death of glial progenitors from the chick retina in…
Changes in cannabis use post decriminalisation in mental health care users in South Africa
Abstract Background: Personal cannabis use was decriminalised in South Africa in 2018. Cannabis use increases the risk of mental illness…